Structure‐oriented review of 14‐3‐3 protein isoforms in geriatric neuroscience
作者： Takahiko Umahara , Toshiki Uchihara , Toshihiko Iwamoto
DOI: 10.1111/J.1447-0594.2012.00860.X
关键词:
摘要: This review focuses on the possible relevance of 14-3-3 proteins in geriatric neuroscience. are mainly localized synapses and neuronal cytoplasm. These regulate intracellular signal cascades for differentiation, development, growth, apoptosis survival. Seven isoforms have so far been identified mammals. The binding motifs potential functions now recognized to a wide range functional relevance. First, we provide brief summary molecular structure multiple proteins. Second, involvement common diseases neurology, such as Alzheimer's disease tauopathies, Parkinson's α-synucleinopathies, Huntington's polyglutamine diseases, Creutzfeldt-Jakob prion cerebral infarction, atherosclerosis. Finally, discuss immunohistochemical localization its during postnatal development rat brains basis understanding adult neurogenesis. elucidation isoform-dependent with regard brain might be promising future novel therapeutic interventions neurology.
sci-hub.se 参考文章(89)
Yasuo Takahashi, The 14-3-3 proteins: Gene, gene expression, and function Neurochemical Research. ,vol. 28, pp. 1265- 1273 ,(2003) , 10.1023/A:1024296932670
H Budka, K Ikeda, K Kosaka, M Yoshimura, Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? Clinical Neuropathology. ,vol. 3, pp. 185- 192 ,(1984)
Yasuhiro Kawamoto, Ichiro Akiguchi, Shinichi Nakamura, Yasuyuki Honjyo, Hiroshi Shibasaki, Herbert Budka, 14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains. Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 245- 253 ,(2002) , 10.1093/JNEN/61.3.245
Toshiki Uchihara, Ayako Nakamura, Mineo Yamazaki, Osamu Mori, Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathologica. ,vol. 101, pp. 535- 539 ,(2001) , 10.1007/S004010000306
Toshiki Uchihara, Kuniaki Tsuchiya, Neuropathology of Pick body disease. Handbook of Clinical Neurology. ,vol. 89, pp. 415- 430 ,(2008) , 10.1016/S0072-9752(07)01238-9
Toshiki Uchihara, Ayako Nakamura, Mineo Yamazaki, Osamu Mori, Kenji Ikeda, Kuniaki Tsuchiya, Different conformation of neuronal tau deposits distinguished by double immunofluorescence with AT8 and thiazin red combined with Gallyas method. Acta Neuropathologica. ,vol. 102, pp. 462- 466 ,(2001) , 10.1007/S004010100401
Natalie Ostrerova, Leonard Petrucelli, Matthew Farrer, Nitinkumar Mehta, Peter Choi, John Hardy, Benjamin Wolozin, α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins The Journal of Neuroscience. ,vol. 19, pp. 5782- 5791 ,(1999) , 10.1523/JNEUROSCI.19-14-05782.1999
Marlène Richard, Anne-Gaëlle Biacabe, Nathalie Streichenberger, James Ironside, Michel Mohr, Nicolas Kopp, Armand Perret-Liaudet, Immunohistochemical localization of 14.3.3 ζ protein in amyloid plaques in human spongiform encephalopathies Acta Neuropathologica. ,vol. 105, pp. 296- 302 ,(2003) , 10.1007/S00401-002-0642-5
Tatsunori Seki, Yasumasa Arai, The persistent expression of a highly polysialylated NCAM in the dentate gyrus of the adult rat. Neuroscience Research. ,vol. 12, pp. 503- 513 ,(1991) , 10.1016/S0168-0102(09)80003-5
Golam Sadik, Toshihisa Tanaka, Kiyoko Kato, Kentaro Yanagi, Takashi Kudo, Masatoshi Takeda, Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3ζ protein Biochemical and Biophysical Research Communications. ,vol. 383, pp. 37- 41 ,(2009) , 10.1016/J.BBRC.2009.03.107