NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders.
作者： Sarah A. Monaco , Yelena Gulchina , Wen-Jun Gao
DOI: 10.1016/J.NEUBIOREV.2015.06.022
关键词:
摘要: The prefrontal cortex (PFC) is a brain region featured with working memory function. exact mechanism of how operates within the PFC circuitry unknown, but persistent neuronal firing recorded from neurons during task proposed to be neural correlate this mnemonic encoding. appears specialized for sustaining firing, N-methyl-D-aspartate (NMDA) receptors, especially slow-decay NR2B subunits, playing an essential role in maintenance sustained activity and normal However, subunit serves as double-edged sword Because its slow kinetics, endows not only "neural psychic" properties, also susceptibilities neuroexcitotoxicity psychiatric disorders. This review aims clarify interplay among memory, PFC, NMDA receptors; demonstrate importance activity; understand risks vulnerabilities related development neuropsychiatric disorders; identify gaps that currently exist our understanding these processes; provide insights regarding future directions may issues. We conclude distinct delayed maturation, unique circuitry, characteristic receptor properties enrichment endow capability generate major vulnerability environmental insults risk factors
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