Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats
作者： Mahmoud Hussein Hassan Ali , Basim Anwar Shehata Messiha , Hekma Abdel-Tawab Abdel-Latif
DOI: 10.3109/13880209.2015.1060247
关键词:
摘要: AbstractContext: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic disease. Resveratrol (RSV) and N-acetylcysteine (NAC) are safe representatives of natural synthetic antioxidants, respectively.Objective: The objective this study was to evaluate protective effects RSV NAC, compared with ursodeoxycholic acid (UDCA), on experimental NAFLD.Materials methods: NAFLD induced by feeding rats a methionine choline-deficient diet (MCDD) for four cycles, each 4 d MCDD 3 d fasting. Animals were divided into normal control, steatosis five treatment groups, receiving UDCA (25 mg/kg/d), (10 mg/kg/d), NAC (20 mg/kg/d), UDCA + RSV, UDCA + NAC orally 28 d. Liver integrity markers (liver index serum transaminases), tumor necrosis factor-α (TNF-α), glucose, albumin, renal functions (urea, creatinine), lipid profile (total cholesterol; TC, triglycerides, high density lipoproteins, low lipoproteins; LDL-C, very den...
informahealthcare.com参考文章(119)
Duangporn Thong-Ngam, MD Onanong Kulaputana, Naruemon Klaikeaw, None, Effects of N-acetylcysteine on oxidative stress in rats with non-alcoholic steatohepatitis. Journal of the Medical Association of Thailand Chotmaihet thangphaet. ,vol. 90, pp. 788- 797 ,(2007)
A.M. Diehl, Z. Goodman, K.G. Ishak, Alcohollike liver disease in nonalcoholics: A clinical and histologic comparison with alcohol-induced liver injury Gastroenterology. ,vol. 95, pp. 1056- 1062 ,(1988) , 10.1016/0016-5085(88)90183-7
Vettickattuparambil George Giby, Thekkuttuparambil Ananthanarayanan Ajith, Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease. World Journal of Hepatology. ,vol. 6, pp. 570- 579 ,(2014) , 10.4254/WJH.V6.I8.570
Qin Yang, Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats World Journal of Gastroenterology. ,vol. 11, pp. 4953- 4956 ,(2005) , 10.3748/WJG.V11.I32.4953
Yi Ding, Xin Sun, Yuning Chen, Yue Deng, Ke Qian, Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet European Journal of Pharmacology. ,vol. 761, pp. 405- 412 ,(2015) , 10.1016/J.EJPHAR.2015.05.005
Johannes Weiß, Monika Rau, Andreas Geier, Non-alcoholic fatty liver disease: epidemiology, clinical course, investigation, and treatment. Deutsches Arzteblatt International. ,vol. 111, pp. 447- 452 ,(2014) , 10.3238/ARZTEBL.2014.0447
Salamah Mohammad Alwahsh, Gesa Martius, Margret Rave-Fränk, Clemens Friedrich Hess, Ihtzaz Ahmed Malik, Giuliano Ramadori, Hans Christiansen, Hepatic fat accumulation and regulation of FAT/CD36: An effect of hepatic irradiation International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 5379- 5392 ,(2014)
Kazushi Sugimoto, Yoshiyuki Takei, Clinicopathological features of non-alcoholic fatty liver disease Hepatology Research. ,vol. 41, pp. 911- 920 ,(2011) , 10.1111/J.1872-034X.2011.00867.X
Vandréa De Souza, Aoumeur Hadj-Aissa, Olga Dolomanova, Muriel Rabilloud, Nicolas Rognant, Sandrine Lemoine, Sylvie Radenne, Jérôme Dumortier, Colette Chapuis-Cellier, Françoise Beyerle, Chantal Bon, Jean Iwaz, Luciano Selistre, Laurence Dubourg, Creatinine- versus cystatine C-based equations in assessing the renal function of candidates for liver transplantation with cirrhosis Hepatology. ,vol. 59, pp. 1522- 1531 ,(2014) , 10.1002/HEP.26886
Q Ye, J Guzman, S Nakamura, R Sarria, U Costabel, A Cu, N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro. Sarcoidosis Vasculitis and Diffuse Lung Diseases. ,vol. 26, pp. 147- 154 ,(2009)