IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm.
作者： Judith Schlupf , Herbert Steinbeisser
DOI: 10.1016/J.DIFF.2014.07.003
关键词:
摘要: Mouse F9 teratocarcinoma cells are an established model for the differentiation of extra-embryonic endoderm (ExEn). Primitive endoderm, parietal and visceral can be generated by stimulation with retinoic acid dibutyryl cyclic adenosine monophosphate. Here we show that Wnt/β-Catenin signaling is down-regulated during ExEn in inhibition Wnt pathway promotes three lineages. achieved through IGF pathway, which up-regulated differentiation. antagonizes stimulating transcription axin2 stabilizing Axin1 protein. Both Axin2 components β-Catenin destruction complex act as intra-cellular inhibitors pathway. The data presented reveal a mechanism restricts pluripotency undifferentiated directs them toward
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