Immunohistochemical localisation of RET and p53 mutant protein of thyroid lesions in a North-Eastern Malaysian population and its prognostic implications

摘要: Summary Aims To investigate RET and p53 expression in local thyroid lesions, order to shed light on the pathogenesis of papillary carcinoma explain high prevalence this condition among nodular hyperplasia (multi-nodular goitre) cases. Methods Archival tissue was retrieved from Hospital Universiti Sains Malaysia (HUSM) Pathology Department files studied by immunohistochemistry for mutant protein. Normal tissues 74 cases served as controls. Results Fifty follicular adenoma, 66 53 were studied. expressed 5.4% normal tissue, 18% adenomas, 22.7% 71.7% carcinomas. Its not associated with coexistence lesions. 17% No association found between or without co-existing carcinoma. p53, rather than RET, an excellent predictor tumour lymph node metastasis capsular invasion. also a significant prognosticator survival outcome. Conclusions is highly prevalent carcinoma, indicating role tumour, no apparent behaviour other hand appears be factor latter events. The two genes appear act different pathways: former being initiator, later propagator