3D printed microneedles for insulin skin delivery
作者： Cristiane Patricia Pissinato Pere , Sophia N. Economidou , Gurprit Lall , Clémentine Ziraud , Joshua S. Boateng
DOI: 10.1016/J.IJPHARM.2018.03.031
关键词:
摘要: In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone designs followed inkjet print coating insulin formulations. Trehalose, mannitol xylitol used as drug carriers with aim preserve integrity stability but also facilitate rapid release rates. Circular dichroism Raman analysis demonstrated that all maintained native form insulin, presenting best performance. Franz cell studies in vitro determination rates porcine skin. Insulin released rapidly within 30 min irrespectively design. proved an effective technology fabrication scalable patches.
kent.ac.uk
gre.ac.uk
core.ac.uk
sci-hub.se 参考文章(37)
Kevin Ita, Transdermal Delivery of Drugs with Microneedles—Potential and Challenges Pharmaceutics. ,vol. 7, pp. 90- 105 ,(2015) , 10.3390/PHARMACEUTICS7030090
Md Jasim Uddin, Nicolaos Scoutaris, Pavlos Klepetsanis, Babur Chowdhry, Mark R. Prausnitz, Dennis Douroumis, Inkjet printing of transdermal microneedles for the delivery of anticancer agents. International Journal of Pharmaceutics. ,vol. 494, pp. 593- 602 ,(2015) , 10.1016/J.IJPHARM.2015.01.038
Shilpa Kaushik, Allen H. Hord, Donald D. Denson, Devin V. McAllister, Sudhasinee Smitra, Mark G. Allen, Mark R. Prausnitz, Lack of pain associated with microfabricated microneedles. Anesthesia & Analgesia. ,vol. 92, pp. 502- 504 ,(2001) , 10.1097/00000539-200102000-00041
Fernanda Andrade, Pedro Fonte, Mireia Oliva, Mafalda Videira, Domingos Ferreira, Bruno Sarmento, Solid state formulations composed by amphiphilic polymers for delivery of proteins: characterization and stability. International Journal of Pharmaceutics. ,vol. 486, pp. 195- 206 ,(2015) , 10.1016/J.IJPHARM.2015.03.050
Narasimha Sreerama, Robert W. Woody, Estimation of Protein Secondary Structure from Circular Dichroism Spectra: Comparison of CONTIN, SELCON, and CDSSTR Methods with an Expanded Reference Set Analytical Biochemistry. ,vol. 287, pp. 252- 260 ,(2000) , 10.1006/ABIO.2000.4880
Maelíosa T.C. McCrudden, Ahlam Zaid Alkilani, Cian M. McCrudden, Emma McAlister, Helen O. McCarthy, A. David Woolfson, Ryan F. Donnelly, Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs Journal of Controlled Release. ,vol. 180, pp. 71- 80 ,(2014) , 10.1016/J.JCONREL.2014.02.007
Shaun D Gittard, Philip R Miller, Chunming Jin, Timothy N Martin, Ryan D Boehm, Bret J Chisholm, Shane J Stafslien, Justin W Daniels, Nicholas Cilz, Nancy A Monteiro-Riviere, Adnan Nasir, Roger J Narayan, None, Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles JOM. ,vol. 63, pp. 59- 68 ,(2011) , 10.1007/S11837-011-0093-3
Nai-Teng Yu, C.S. Liu, D.C. O'Shea, Laser Raman spectroscopy and the conformation of insulin and proinsulin Journal of Molecular Biology. ,vol. 70, pp. 117- 132 ,(1972) , 10.1016/0022-2836(72)90167-2
Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz, Microneedles for drug and vaccine delivery. Advanced Drug Delivery Reviews. ,vol. 64, pp. 1547- 1568 ,(2012) , 10.1016/J.ADDR.2012.04.005
Roger J. Narayan, Transdermal delivery of insulin via microneedles. Journal of Biomedical Nanotechnology. ,vol. 10, pp. 2244- 2260 ,(2014) , 10.1166/JBN.2014.1976