Comprehensive nutraceutical agent for treatment/ prevention of Parkinson's disease

摘要: This invention discloses a comprehensive nutraceutical designed to antagonize major mitigating factors specific the degenerative process that occurs in Parkinson's disease (PD). The formulation is comprised of pyruvate, succinate and/or oxaloacetate further combined with macro/micronutrients, trace elements, amino acids, flavonoids and concentrated plant sources. formula based on means attenuate loss ATP/toxicity by PD model toxins: 1-methyl-4-phenylpyridinium rotenone, scavenge hydrogen peroxide/O 2 , augment antioxidant enzymes, prevent dopamine oxidation DA-quinone via inhibition COX, PLA LOX, xanthine oxidase, tyrosinase, hyperhomocysteinemia, PARP-1 apoptosis, increase blood flow, glucose oxygen delivery brain, potentiate mitochondrial function, glia iNOS MAO or its products, chelate redox-active iron, inhibit hemeoxygenase-1, alpha-synuclein aggregation, ATP storage, mediate anti-inflammatory effects inhibition. PDE, MAPK p38/c-Jun NH2-terminal kinase/PGE2, excitotoxicity downregulate N-methyltransferase, all which contribute toward pathology.