Peak oxygen uptake and incident coronary heart disease in a healthy population: the HUNT Fitness Study

摘要: Aims The majority of previous research on the association between cardiorespiratory fitness (CRF) and cardiovascular disease (CVD) is based indirect assessment CRF in clinically referred predominantly male populations. Therefore, our aim was to examine associations VO2peak measured by gold-standard method cardiopulmonary exercise testing fatal non-fatal coronary heart (CHD) a healthy fit population. Methods results Data from 4527 adults (51% women) with no history or lung disease, cancer, hypertension use antihypertensive medications participating large population-based health-study (The HUNT3 Study), were linked hospital registries cause death registry. Average 36.0 mL/kg/min 44.4 among women men, 83.5% had low 10-year risk CVD at baseline. follow-up 8.8 years, 147 participants reached primary endpoint. Multi-adjusted Cox-regression showed 15% lower for endpoint per one-MET (metabolic equivalent task) higher [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77-0.93], similar across sex. highest quartile 48% event compared lowest (multi-adjusted HR 0.52, CI 0.33-0.82). Oxygen pulse ventilatory equivalents oxygen carbon dioxide also significant predictive value Conclusion strongly inversely associated CHD whole continuum low-risk population sample. Increasing may have substantial benefits reducing burden CHD.