Telomeres and human aging: facts and fibs.

摘要: Can telomere dynamics, defined by length and attrition rate, provide information about the biology of human aging above beyond that provided chronological age? Accruing data suggest it can. White blood cells (WBCs) have been used as primary model in attempts to decipher links between aging, aging-related disorders, dynamics humans. The WBC may be appropriate clinical settings, we fully appreciate its drawbacks limitations. On basis data, is evident age-adjusted highly variable, heritable, longer women than men, shorter people who harbor a host age-related whose common denominators prove increased oxidative stress inflammation. It appears augurs greater risk morbidity premature mortality elderly. However, unsettled whether only proxy for fundamental mechanisms govern course or key determinant progression.