作者: Siham Serraj , Pierre Michaïlesco , Jacques Margerit , Bruce Bernard , Philippe Boudeville
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摘要: Calcium phosphate-based cements (CPCs) have attracted much interest because of their good osteoconductivity for bone reconstruction. We obtained CPCs by mixing calcium bis-dihydrogenophosphate monohydrate (MCPM) and oxide with water or sodium phosphate buffers (NaP) as liquid phase. Cement samples different calcium-to-phosphate ratios (Ca/P), liquid-to-powder (L/P) phases were analyzed X-rays diffraction (XRD), pH-metry, extensometry calorimetry. Antibacterial activity on two bacterial strains (Streptococcus mutans, Lactobacillus acidophilus) a polycontaminated inoculum was also studied using the agar diffusion method. The best mechanical properties (approximately 25 MPa) corresponded to Ca/P between 1.67 2.5, 1 M buffer pH 7, phase L/P ratio 0.6ml g(-1). final setting time increased ratio. expansion, around 1-2%, depended ratios. inner temperature rose 45 degrees during then decreased rapidly. injectability 100% up 3.5 min decreased. It increasing but detriment compressive strength time. XRD analysis indicated that reaction led mixture hydroxide calcium-deficient hydroxyapatite even 1.67. Consequently, surrounding fluids 11.5-12 dissolution. Bacterial growth inhibition only clearly observed Ca/P>or=2. This bioactive cement can potentially be employed pulp capping cavity lining classical hydroxide-based cements, it is not usable, in present formulation, root canal filling its short