Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies.

摘要: There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions practice biologic orthopedics result simplified principle platelets deliver growth factors, cause inflammation, and singular value bone marrow is stem cells. The aim this review to address these common misconceptions which will enable better development future orthopedic medical devices. WBC behavior adaptive nature and, depending on their environment, can hinder or induce healing. Successful tissue repair occurs when arrive at a wound site, degranulate, release factors cytokines which, turn, recruit damaged tissue. Therefore, key even pure platelet-rich plasma wound. Bone contains complex mixture vascular cells, present much greater concentrations than blood, small number progenitor negative results observed for WBC-containing therapies vitro have not translated human clinical studies. With an enhanced understanding biology, next generation biologics be more specific, likely resulting improved effectiveness.