Effects of prenatal stress and monoaminergic perturbations on the expression of serotonin 5-HT4 and adrenergic β2 receptors in the embryonic mouse telencephalon
作者： Angela Chen , Lauren D.S. Kelley , Skirmantas Janušonis
DOI: 10.1016/J.BRAINRES.2012.04.019
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摘要: Abstract The serotonin 5-HT4 receptor (5-HT4R) is coded by a complex gene that produces four mRNA splice variants in mice (5-HT4(a)R, 5-HT4(b)R, 5-HT4(e)R, 5-HT4(f)R). This has highly dynamic expression brain development and its differ their developmental trajectories. Since 5-HT4Rs are important forebrain function (including control of serotonergic activity the brainstem), we investigated susceptibility 5-HT4R mouse embryonic telencephalon to prenatal maternal stress altered (5-hydroxytryptamine, 5-HT) levels. Because coding adrenergic β2 (β2AR) embedded gene, also whether levels were modulated selective β2AR agents. Timed-pregnant C57BL/6 treated beginning at day (E) 14 quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was used assess all E17. Maternal 5-HT depletion with pCPA, tryptophan hydroxylase inhibitor, reduced 5-HT4(b)R variant. Terbutaline (a agonist) ICI 118,551 antagonist) had no effect on These results show can alter developing some may be more susceptible than others.
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