Synthesis, physico-chemical characterization, antimicrobial activity and toxicological features of AgZnO nanoparticles

摘要: Abstract Silver-zinc oxide nanoparticles (Ag ZnO NPs) were chemically synthesized by the deposition of Ag NPs on surface using silver nitrate, three types anionic polyelectrolytes and citric acid as reagents. The Wavelength Dispersive X-ray Fluorescence (WDXRF) spectrometry revealed 0.41–0.69 wt% Ag, balance ZnO. existence with hexagonal wurtzite structure was highlighted Diffraction (XRD) analysis, scanning electron microscopy (SEM), Ultraviolet–Visible (UV–Vis) spectroscopy. diffuse reflectance absorption in visible light region increased increase content. Fourier Transform Infrared (FTIR) no chemical bonding between confirmed presence functional groups characteristic to carboxylic salts. newly displayed antimicrobial activity against all tested medically relevant pathogens, minimal (biofilm) inhibitory concentrations ranging from 1.875 mg/mL 7.5 mg/mL. Although vitro genotoxicity assay a relatively high micronuclei index, vivo micronucleus (MN) test low MN frequency animals treated NPs. histopathological analysis non-significant structural changes hepatic parenchyma, renal cortex intestinal mucosa inflammatory reactions. administration induced TUNEL positive nuclei Kupffer cells liver parenchyma. present study shows that are active planktonic adherent microorganisms could be exploited develop novel strategies for biotechnology biomedical fields. Easy scalability developed synthesis is major advantage producing large batches reproducible properties.