Role of dihydropyrimidine dehydrogenase and thymidylate synthase expression in immunohistochemistry of intrahepatic cholangiocarcinoma

摘要: Aims:  Dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are key enzymes in the metabolism of 5-fluorouracil have been implicated as possible prognostic markers for cancer patients. However, clinical roles DPD TS intrahepatic cholangiocarcinoma (IHCC) not investigated. The aim this study was to clarify clinicopathological role expressions IHCC. Methods:  Twenty-nine patients who had undergone hepatic resection IHCC were enrolled study. Expressions resected specimens examined using anti-DPD or anti-TS antibody. divided into positive negative groups according DPD/TS expressions: DPD-positive group (n = 18) DPD-negative (n = 11)/TS-positive (n = 14) TS-negative (n = 15). Clinicopathological factors compared between two groups. Results:  overall survival rate significantly lower than (1-year 36.4% vs. 77.4%, 3-year 18.2% 43.0%; P < 0.05). disease-free tended be that group. did appear associated with TS-expression status. Ki-67 labeling index higher (16.9 ± 3.2% vs.13.2 ± 3.3%; P < 0.05). Conclusions:  expression enhanced tumor cell proliferation poorer prognosis IHCC. is a potential indicator