The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases

摘要: Chronic obstructive pulmonary disease (COPD) includes a spectrum of conditions that have in common varying degrees airflow obstruction, such as chronic bronchitis and emphysema. There is an increasing evidence involvement sphingolipids key molecular mediators or biomarkers emphysema, bronchitis, more recently asthma, another characterized by (reversible) obstruction. Given the recognized central role oxidative stress inflammatory stimuli along with immune responses, apoptosis, tissue remodeling development lung diseases, it not surprising been shown to play important their pathobiology. In particular pro-apoptotic effects ceramide were suspected events destruction occurs result apoptotic loss structural cells comprising alveolar walls, microvascular endothelial epithelial cells. addition, was investigated models larger airway cell responses cigarette smoke, context ensuing inflammation. This chapter discusses current sphingolipid perturbations experimental COPD relevant links human based on translational epidemiological data.