Temporal effects of mancozeb on testes, accessory reproductive organs and biochemical constituents in albino mice

摘要: Mancozeb, a fungicide of ethylenebisdithiocarbamate group was orally administered at 800 mg/kg body weight to male Swiss albino mice for 5, 10, 20 and 30 days. Daily the were recorded. The sacrificed by cervical dislocation after 24 h terminal exposure mancozeb. Testes decreased significantly in days mancozeb treated mice. However, there significant decrease number spermatogonia, diameter spermatocytes spermatids 10 Histologic studies testis with long duration revealed spermatogenesis inhibition reflected spermatogenic cells sperms, when compared that controls. In showed prostate gland. However Cowper's glands There kidney, spleen liver weight, where as thyroid increased thymus only caused level protein increase total lipids testis. glycogen kidney. levels protein, These observed effects on biochemical constituents may be due hormonal imbalance any stages hypothalamo-hypophysial-testicular axis.