Example for Small Molecule Modeling: Serotonin Receptor Ligands

Christine Humblet, Taraneh Mirzadegan, Chapter 30. Three-dimensional Models of G-Protein Coupled Receptors Annual Reports in Medicinal Chemistry. ,vol. 27, pp. 291- 300 ,(1992) , 10.1016/S0065-7743(08)60428-5

Hung-Teh Kao, Nika Adham, Michael A. Olsen, Richard L. Weinshank, Theresa A. Branchek, Paul R. Hartig, Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology. FEBS Letters. ,vol. 307, pp. 324- 328 ,(1992) , 10.1016/0014-5793(92)80705-L

Jeff L. Herndon, Abd Ismaiel, Stacy P. Ingher, M. Teitler, Richard A. Glennon, Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. Journal of Medicinal Chemistry. ,vol. 35, pp. 4903- 4910 ,(1992) , 10.1021/JM00104A017

Klaus P. Boegesoe, Joern Arnt, Vita Boeck, A. Vibeke Christensen, John Hyttel, Klaus Gundertofte Jensen, Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. Journal of Medicinal Chemistry. ,vol. 31, pp. 2247- 2256 ,(1988) , 10.1021/JM00120A003

Susanne Trumpp-Kallmeyer, Jan Hoflack, Anne Bruinvels, Marcel Hibert, Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors. Journal of Medicinal Chemistry. ,vol. 35, pp. 3448- 3462 ,(1992) , 10.1021/JM00097A002

Hans-Dieter Höltje, Uwe Klaus Jendretzki, Construction of a Detailed Serotoninergic 5-HT2a Receptor Model Archiv der Pharmazie. ,vol. 328, pp. 577- 584 ,(1995) , 10.1002/ARDP.19953280704

B K Kobilka, S J Peroutka, X M Guan, Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors. Molecular Pharmacology. ,vol. 41, pp. 695- 698 ,(1992)

Yoshifumi WATANABE, Hiroyuki USUI, Toshiro SHIBANO, Tsuyoshi TANAKA, Munefumi KANAO, Syntheses of monocyclic and bicyclic 2,4(1H,3H)-pyrimidinediones and their serotonin 2 antagonist activities. Chemical & Pharmaceutical Bulletin. ,vol. 38, pp. 2726- 2732 ,(1990) , 10.1248/CPB.38.2726