Characterization and Liquid Chromatography-MS/MS Based Quantification of Hydroxylated Fullerenes
作者： Tzu-Chiao Chao , Guixue Song , Nicole Hansmeier , Paul Westerhoff , Pierre Herckes
DOI: 10.1021/AC1031379
关键词:
摘要: Highly water-soluble hydroxylated fullerene derivatives are being investigated for a wide range of commercial products as well potential cytotoxicity. However, no analytical methods currently available their quantification at sub-ppm concentrations in environmental matrixes. Here, we report on the development and comparison liquid chromatography-ultraviolet/visible spectroscopy (LC-UV/vis) chromatography-mass spectrometry (LC-MS) based detection fullerols. We achieved good separation efficiency using an amide-type hydrophilic interaction chromatography (HILIC) column (plate number >2000) under isocratic conditions with 90% acetonitrile mobile phase. The method limits (MDLs) ranged from 42.8 ng/mL (UV detection) to 0.19 pg/mL (using MS multiple reaction monitoring, MRM). Other measurement modes MDLs 125 (single quad scan, Q1) 1.5 (multiple ion MI). Each me...
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Carl W. Isaacson, Crystal Y. Usenko, Robert L. Tanguay, Jennifer A. Field, Quantification of fullerenes by LC/ESI-MS and its application to in vivo toxicity assays. Analytical Chemistry. ,vol. 79, pp. 9091- 9097 ,(2007) , 10.1021/AC0712289
Jaesang Lee, Yuri Mackeyev, Min Cho, Dong Li, Jae-Hong Kim, Lon J Wilson, Pedro JJ Alvarez, None, Photochemical and antimicrobial properties of novel C60 derivatives in aqueous systems. Environmental Science & Technology. ,vol. 43, pp. 6604- 6610 ,(2009) , 10.1021/ES901501K
Mauro Ferrari, Cancer nanotechnology: opportunities and challenges Nature Reviews Cancer. ,vol. 5, pp. 161- 171 ,(2005) , 10.1038/NRC1566
Yasukazu Saitoh, Li Xiao, Hiromi Mizuno, Shinya Kato, Hisae Aoshima, Hikaru Taira, Ken Kokubo, Nobuhiko Miwa, Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes Free Radical Research. ,vol. 44, pp. 1072- 1081 ,(2010) , 10.3109/10715762.2010.499905
Vukosava Milic Torres, Branislava Srdjenovic, Vesna Jacevic, Viktorija Dragojevic Simic, Aleksandar Djordjevic, Ana Luísa Simplício, Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats Pharmacological Reports. ,vol. 62, pp. 707- 718 ,(2010) , 10.1016/S1734-1140(10)70328-5
Najla Gharbi, Stephan Burghardt, Michael Brettreich, Christine Herrenknecht, Sara Tamisier-Karolak, René Victor Bensasson, Henri Szwarc, Andreas Hirsch, Stephen R. Wilson, Fathi Moussa, Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid. Analytical Chemistry. ,vol. 75, pp. 4217- 4222 ,(2003) , 10.1021/AC026419K
K. D. Pickering, M. R. Wiesner, Fullerol-sensitized production of reactive oxygen species in aqueous solution. Environmental Science & Technology. ,vol. 39, pp. 1359- 1365 ,(2005) , 10.1021/ES048940X
Léna Brunet, Delina Y. Lyon, Ernest M. Hotze, Pedro J. J. Alvarez, Mark R. Wiesner, Comparative Photoactivity and Antibacterial Properties of C60 Fullerenes and Titanium Dioxide Nanoparticles Environmental Science & Technology. ,vol. 43, pp. 4355- 4360 ,(2009) , 10.1021/ES803093T
Michael V. Ugarov, T. Egan, Dmitry V. Khabashesku, J. Albert Schultz, Haiqing Peng, Valery N. Khabashesku, Hiroshi Furutani, Kimberley S. Prather, H-W. J. Wang, S. N. Jackson, Amina S. Woods, MALDI Matrices for Biomolecular Analysis Based on Functionalized Carbon Nanomaterials Analytical Chemistry. ,vol. 76, pp. 6734- 6742 ,(2004) , 10.1021/AC049192X
Shigeru Yamago, Hidetoshi Tokuyama, Eiichi Nakamura, Koichi Kikuchi, Shinji Kananishi, Keisuke Sueki, Hiromichi Nakahara, Shuichi Enomoto, Fumitoshi Ambe, In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity Chemistry & Biology. ,vol. 2, pp. 385- 389 ,(1995) , 10.1016/1074-5521(95)90219-8