Cell Cycle Deregulation and TP53 and RAS Mutations Are Major Events in Poorly Differentiated and Undifferentiated Thyroid Carcinomas
作者： Jaime Miguel Pita , Inês Filipa Figueiredo , Margarida Maria Moura , Valeriano Leite , Branca Maria Cavaco
DOI: 10.1210/JC.2013-1512
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摘要: Background: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies, for which there is no effective treatment. Objective: In present study, we aimed to elucidate molecular alterations contributing ATC development and identify novel therapeutic targets. Design: We profiled global gene expression of five ATCs validated differentially expressed genes by quantitative RT-PCR in an independent set tumors. a series 26 ATCs, searched pathogenic involved deregulated cellular processes, including hot spot regions RAS, BRAF, TP53, CTNNB1 (β-catenin), PIK3CA genes, and, first time, comprehensive analysis components cell cycle [cyclin-dependent kinase (CDK) inhibitors (CDKI): CDKN1A (p21CIP1); CDKN1B (p27KIP1); CDKN2A (p14ARF, p16INK4A); CDKN2B (p15INK4B); CDKN2C (p18INK4C)], adhesion (AXIN1), proliferation (PTEN). Mutational was also performed 22 poorly differentiate...
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