A polycystin-centric view of cyst formation and disease: the polycystins revisited
作者： Albert C.M. Ong , Peter C. Harris
DOI: 10.1038/KI.2015.207
关键词:
摘要: It is 20 years since the identification of PKD1, major gene mutated in autosomal dominant polycystic kidney disease (ADPKD), followed closely by cloning PKD2. These breakthroughs have led turn to a period intense investigation into function two proteins encoded, polycystin-1 and polycystin-2, how defects either protein lead cyst formation nonrenal phenotypes. In this review, we summarize findings area present current model polycystin health disease.
elsevier.com
kidney-international.org
core.ac.uk
nature.com
sci-hub.se 参考文章(198)
Ye Chen, Zheng Zhang, Xiao-Yan Lv, Yi-Dong Wang, Zhong-Guo Hu, Huan Sun, Rui-Zhi Tan, Yu-Hang Liu, Guo-Hui Bian, Yan Xiao, Qin-Wei Li, Qiu-Tan Yang, Jian-Zhong Ai, Lu Feng, Yang Yang, Yu-Quan Wei, Qin Zhou, Expression of Pkd2l2 in testis is implicated in spermatogenesis. Biological & Pharmaceutical Bulletin. ,vol. 31, pp. 1496- 1500 ,(2008) , 10.1248/BPB.31.1496
A. J. Streets, B. E. Wagner, P. C. Harris, C. J. Ward, A. C. M. Ong, Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells Journal of Cell Science. ,vol. 122, pp. 1410- 1417 ,(2009) , 10.1242/JCS.045021
Tom J. G. Gevers, Joost P. H. Drenth, Diagnosis and management of polycystic liver disease Nature Reviews Gastroenterology & Hepatology. ,vol. 10, pp. 101- 108 ,(2013) , 10.1038/NRGASTRO.2012.254
Evelyne Fischer, Emilie Legue, Antonia Doyen, Faridabano Nato, Jean-François Nicolas, Vicente Torres, Moshe Yaniv, Marco Pontoglio, Defective planar cell polarity in polycystic kidney disease Nature Genetics. ,vol. 38, pp. 21- 23 ,(2006) , 10.1038/NG1701
Hyunho Kim, Hangxue Xu, Qin Yao, Weizhe Li, Qiong Huang, Patricia Outeda, Valeriu Cebotaru, Marco Chiaravalli, Alessandra Boletta, Klaus Piontek, Gregory G. Germino, Edward J. Weinman, Terry Watnick, Feng Qian, Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism Nature Communications. ,vol. 5, pp. 5482- 5482 ,(2014) , 10.1038/NCOMMS6482
Claas Wodarczyk, Gianfranco Distefano, Isaline Rowe, Massimiliano Gaetani, Barbara Bricoli, Mordi Muorah, Andrea Spitaleri, Valeria Mannella, Piero Ricchiuto, Monika Pema, Maddalena Castelli, Ariel E. Casanova, Luca Mollica, Manuela Banzi, Manila Boca, Corinne Antignac, Sophie Saunier, Giovanna Musco, Alessandra Boletta, Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals PLoS ONE. ,vol. 5, pp. e12719- ,(2010) , 10.1371/JOURNAL.PONE.0012719
S. Gonzalez-Perrett, K. Kim, C. Ibarra, A. E. Damiano, E. Zotta, M. Batelli, P. C. Harris, I. L. Reisin, M. A. Arnaout, H. F. Cantiello, Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 1182- 1187 ,(2001) , 10.1073/PNAS.98.3.1182
Feng Qian, F. Joseph Germino, Yiqiang Cai, Xiangbin Zhang, Stefan Somlo, Gregory G. Germino, PKD1 interacts with PKD2 through a probable coiled-coil domain Nature Genetics. ,vol. 16, pp. 179- 183 ,(1997) , 10.1038/NG0697-179
Ben Fogelgren, Shin-Yi Lin, Xiaofeng Zuo, Kimberly M. Jaffe, Kwon Moo Park, Ryan J. Reichert, P. Darwin Bell, Rebecca D. Burdine, Joshua H. Lipschutz, The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLOS Genetics. ,vol. 7, ,(2011) , 10.1371/JOURNAL.PGEN.1001361
Michael Köttgen, Thomas Benzing, Thomas Simmen, Robert Tauber, Björn Buchholz, Sylvain Feliciangeli, Tobias B Huber, Bernhard Schermer, Albrecht Kramer-Zucker, Katja Höpker, Katia Carmine Simmen, Christoph Carl Tschucke, Richard Sandford, Emily Kim, Gary Thomas, Gerd Walz, Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. The EMBO Journal. ,vol. 24, pp. 705- 716 ,(2005) , 10.1038/SJ.EMBOJ.7600566