State disparities in colorectal cancer rates: Contributions of risk factors, screening, and survival differences

摘要: BACKGROUND Northeastern states of the United States have shown more progress in reducing colorectal cancer (CRC) incidence and mortality rates than Southern states, this has resulted considerable disparities. This study quantified how disparities CRC between Louisiana (a state) New Jersey would be affected if differences risk factors, screening, stage-specific relative survival were eliminated. METHODS used Microsimulation Screening Analysis Colon microsimulation model to estimate age-adjusted from 1995 2009 under assumption that 1) had same smoking obesity prevalence observed Jersey, 2) screening uptake 3) or 4) all preceding true. RESULTS In 2009, 141.4 cases 61.9 deaths per 100,000 individuals, respectively. With factors rate was reduced by 3.5% 15.2%, Jersey's 3.0%, 10.8%, 17.4%, trends combined, modeled individuals became lower for both (116.4 vs 130.0) (44.7 55.8). CONCLUSIONS The could eliminated attain levels survival. Priority should given enabling improve rates.