Antibody avidity and immunoglobulin G isotype distribution following immunization with a monovalent meningococcal B outer membrane vesicle vaccine.

摘要: [P < 0.0001] for total IgG, r 0.83 IgG1 0.0001], 0.82 IgG3 and 0.84 the avidity titer). When two subgroups with similar anti-OMV IgG levels were compared before after booster vaccination, higher AI vaccination was associated significantly increased SBA. We concluded that maturation occurs a monovalent meningococcal B OMV vaccine, especially boosting, as indicated by significant increase in AI. Vaccination vaccine induced mainly isotypes, which are considered to be most important protection against disease. An of antibodies is SBA, independent level specific isotype distribution. Measuring distribution can supplementary method predicting protective immunity evaluation future phase III trials serogroup vaccines. Neisseria meningitidis an cause meningitis septicemia worldwide. In many countries Western Europe, N. frequently isolated from seriously ill patients. struggle disease caused this serogroup, great efforts have been made develop vaccine. The group capsular polysaccharide poorly immunogenic since it shows strong antigenic resemblance structures expressed on human fetal neural cells (12). As consequence, may induce cross-react tissues. Therefore, vaccines containing outer membrane proteins developed shown immune responses (3, 11). At National Institute Public Health Environment (RIVM), workers consisting vesicle (OMV) preparations, each expressing three different PorA representing majority circulating serosubtypes Netherlands other Europe (7). This