Cranial Irradiation Increases Risk of Stroke in Pediatric Brain Tumor Survivors

摘要: Background and Purpose—The purposes of this study were to determine the incidence neurovascular events as late complications in pediatric patients with brain tumor evaluate radiation a risk factor. Methods—Patients ascertained using database tertiary care center. Included had primary tumor, age birth 21 years, initial treatment January 1, 1993, December 31, 2002, at least 2 visits neuro-oncology. Radiation exposure included: whole brain, plus focal boost, or brain. The outcome was stroke transient ischemic attack. Results—Of 431 subjects, 14 19 attack over median follow-up 6.3 years. rate 548/100 000 person-years. Overall, 61.5% subjects received radiation, including 13 events. Median time from first event 4.9 stroke/transient hazard ratio for any irradiation...