Pharmacokinetic-pharmacodynamic Modeling of Monoamine Oxidase A Inhibitory Activity and Behavior Improvement by Curcumin in the Mouse Forced Swimming Test

摘要: Abstract Aim To characterize the pharmacokinetic, pharmacodynamic and efficacy profiles of curcumin in animal model depression. Methods The forced swimming test (FST) mice was used this study. single repeated (hourly for three times) oral administration 2.5, 5 10 mg·kg−1 performed FST. Brain monoamine oxidase A (MAO-A) vitro vivo as well behaviors were determined. plasma concentration analyzed using high performance liquid chromatography (HPLC) method. pharmacokinetics described by a two-compartment pharmacokinetic with lag time mouse Results peak observed at 0.75 h (single) 2.75–3 (repeated) after administration, around detection limit 6 14 (repeated), respectively. Curcumin nanogram concentrations showed inhibitory activity behavioral improvement maximum effects climbing, immobility achieved 1–2 3–4 which paralleled that MAO-A frontal cortex hippocampus FST, Conclusion These results suggest may indirectly produce improvement, its antidepressant potency not be dependent on concentration.