Genetic Landscape of Slovenians: Past Admixture and Natural Selection Pattern
作者： Pierpaolo Maisano Delser , Metka Ravnik-Glavač , Paolo Gasparini , Damjan Glavač , Massimo Mezzavilla
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摘要: The Slovenian territory played a crucial role in the past serving as gateway for several human migrations. Previous studies used Slovenians source population to interpret different demographic events happened Europe but not much is known about genetic background and history of this population. Here, we analysed genome-wide data from 96 individuals shed light on Y chromosome diversity splits into two major haplogroups R1b R1a with latter suggesting contribution steppe. are more closely related Northern Eastern European populations than Southern even though they geographically closer. This pattern confirmed by an admixture clustering analysis. We also identified single stream between Sardinians Russians around ~2630 BCE (2149-3112). Using ancient samples, found significant event Yamnaya early Neolithic Hungarians dated ~1762 (1099-2426) strong steppe foundation observed modern diversity. Finally, looked signals selection candidate variants hits HERC2 FADS when compared Europeans responsible blue eye colour synthesis long-chain unsaturated fatty acids respectively. When comparison was done Europeans, PKD2L1 IL6R which genes associated taste coronary artery disease
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