Chronic Exposure to Low Levels of Antigen in the Periphery Causes Reversible Functional Impairment Correlating with Changes in CD5 Levels in Monoclonal CD8 T Cells
作者： Panagiota Stamou , James de Jersey , Danielle Carmignac , Clio Mamalaki , Dimitris Kioussis
DOI: 10.4049/JIMMUNOL.171.3.1278
关键词:
摘要: This study describes a double-transgenic model in which monoclonal CD8 F5 T cells are chronically exposed to self Ag (nucleoprotein) the periphery, but not affected during thymic development. Chronic exposure of their cognate rendered them unable proliferate or produce cytokines response antigenic stimulation vitro. However, still retained some killer function vivo and continuously eliminated APC expressing high levels Ag. In addition, when crossed with mice anterior pituitary gland (triple-transgenic mice), migrated this site killed growth hormone producing somatotrophs. The anergic state was reversible upon transfer into Ag-free recipients, resulting full recovery vitro responsiveness Anergic express higher CD5, negative regulator cell signaling, whereas after residence hosts, CD5 returned normal. suggests that up-regulation regulators peripheral chronic by may prevent functionality thus avoid overt autoreactivity.
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