Adult-specific functions of animal microRNAs
作者： Kailiang Sun , Eric C. Lai
DOI: 10.1038/NRG3471
关键词:
摘要: MicroRNAs (miRNAs) are ~22 nt RNAs that coordinate vast regulatory networks in animals and thereby influence myriad processes. This Review examines evidence miRNAs have continuous roles adults ways separable from developmental control. Adult-specific activities for been described various stem cell populations, the context of neural function cardiovascular biology, metabolism ageing, during cancer. In addition to reviewing recent results, we also discuss methods studying miRNA specifically evaluate their relative strengths weaknesses. A fuller understanding functions has bearing on efforts opportunities manipulate therapeutic purposes.
nature.com
sci-hub.se 参考文章(194)
R. J. A. Frost, E. N. Olson, Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 21075- 21080 ,(2011) , 10.1073/PNAS.1118922109
Scott Valastyan, Ferenc Reinhardt, Nathan Benaich, Diana Calogrias, Attila M Szász, Zhigang C Wang, Jane E Brock, Andrea L Richardson, Robert A Weinberg, None, RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis Cell. ,vol. 137, pp. 1032- 1046 ,(2009) , 10.1016/J.CELL.2009.03.047
Wenyu Luo, Amita Sehgal, Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit Cell. ,vol. 148, pp. 765- 779 ,(2012) , 10.1016/J.CELL.2011.12.024
C. G. Crist, D. Montarras, G. Pallafacchina, D. Rocancourt, A. Cumano, S. J. Conway, M. Buckingham, Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 13383- 13387 ,(2009) , 10.1073/PNAS.0900210106
Hila Toledano, Cecilia D’Alterio, Benjamin Czech, Erel Levine, D. Leanne Jones, The let-7 –Imp axis regulates ageing of the Drosophila testis stem-cell niche Nature. ,vol. 485, pp. 605- 610 ,(2012) , 10.1038/NATURE11061
György Hutvágner, Martin J Simard, Craig C Mello, Phillip D Zamore, Sequence-specific inhibition of small RNA function PLOS Biology. ,vol. 2, ,(2004) , 10.1371/JOURNAL.PBIO.0020098
T. Smith-Vikos, F. J. Slack, MicroRNAs and their roles in aging Journal of Cell Science. ,vol. 125, pp. 7- 17 ,(2012) , 10.1242/JCS.099200
Jun Gao, Wen-Yuan Wang, Ying-Wei Mao, Johannes Gräff, Ji-Song Guan, Ling Pan, Gloria Mak, Dohoon Kim, Susan C. Su, Li-Huei Tsai, A novel pathway regulates memory and plasticity via SIRT1 and miR-134 Nature. ,vol. 466, pp. 1105- 1109 ,(2010) , 10.1038/NATURE09271
Jan-Wilhelm Kornfeld, Catherina Baitzel, A. Christine Könner, Hayley T. Nicholls, Merly C. Vogt, Karolin Herrmanns, Ludger Scheja, Cécile Haumaitre, Anna M. Wolf, Uwe Knippschild, Jost Seibler, Silvia Cereghini, Joerg Heeren, Markus Stoffel, Jens C. Brüning, Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b Nature. ,vol. 494, pp. 111- 115 ,(2013) , 10.1038/NATURE11793
R. C. Lee, An Extensive Class of Small RNAs in Caenorhabditis elegans Science. ,vol. 294, pp. 862- 864 ,(2001) , 10.1126/SCIENCE.1065329