Inhibition of hypoxia inducible factor-1α downregulates the expression of epithelial to mesenchymal transition early marker proteins without undermining cell survival in hypoxic lens epithelial cells.
作者： Patrick R. Cammarata , Morgan M. Brooks , Sudha Neelam
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摘要: Purpose The purpose of this study was to identify potential therapeutic strategies slow down or prevent the expression early-onset epithelial mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing synthesis accumulation prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens (HLE) cells.
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