10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K–AKT pathway
作者： Jianguang Wang , Wei Zhang , Hai Zou , Yaoyao Lin , Ke Lin
DOI: 10.1016/J.INTIMP.2015.05.036
关键词:
摘要: Abstract To reveal the mechanism of 10H2DA inhibiting proliferation fibroblast-like synoviocytes (FLSs) RA patients. Cell proliferation, HDAC activity and histone acetylation level FLS cells treated with were detected by MTT assay, Colorimetric Activity Assay Western-blot. Different genes in from patients primary cultured 10H2DA. They then screened Human Transcriptome 1.0 ST microarrays verified real-time PCR. The results showed dose-dependent time-dependent decreases cell viability FLSs 10H2DA, induction H3 H4 at same time. 697 different identified HTA 1.0. expressions 7 target PI3K–AKT pathway decreased 4 cytokine-cytokine receptor interaction increased These imply that is a potential HDACI which inhibits pathway.
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