Enantiocontrolled Synthesis of Spirooxindoles Based on the [5 + 2] Cycloaddition of a Tp(CO)2Mo(pyridinyl) Scaffold (Tp = Hydridotrispyrazolylborate)
作者： Helena C. Malinakova , Lanny S. Liebeskind
DOI: 10.1021/OL000313Z
关键词:
摘要: A [5 + 2] cycloaddition of the pyridinyl π-complex (−)-1 (98% ee) to methyleneoxindole 2 afforded spirooxindole complex (−)-3 in high enantiomeric purity. Complex was converted pyrrolidine (−)-8 (97% ee), which is related potent cytotoxic analogues spirotryprostatins alkaloids.
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