The relative impact of different measures of adiposity on markers of early atherosclerosis

摘要: Abstract Background Although there are several methods available to assess adiposity, is still controversy on the relative clinical utility of each these methods. This study examines impact different measures adiposity markers early atherosclerosis. In particular weight changes over time have been poorly assessed in this setting. Methods Eighty-six healthy individuals (31 men, age 36.5±8.9 years) with a wide range body-mass index (28.7±7.0, 18.9–57.9 kg/m 2 ) without hypertension, diabetes or smoking were examined. addition waist circumference and waist-to-hip ratio self-reported change since adolescence was also calculated. Ultrasonography used measure abdominal fat layers their ratio. Flow-mediated dilatation brachial artery, serum levels intercellular adhesion molecule (sICAM-1) mean intima-media thickness carotid artery measured as Results Stepwise multivariate regression analysis showed only independent predictor flow-mediated dilatation. Waist but not current predictors thickness. These correlations influenced by ultrasonographically layers, C-reactive protein basal insulin resistance. Body-mass gain associated sICAM-1 independently resistance protein. Conclusions strongest atherosclerosis population apparently adults. The did provide additional information population.