Pazopanib (Votrient): A VEGFR Tyrosine Kinase Inhibitor for Cancer

作者: Ji Zhang , Jie Jack Li

DOI: 10.1002/9780470768594.CH9

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参考文章(18)
I.I. Baskin, E.V. Radchenko, V.A. Palyulin, N.S. Zefirov, A.A. Ivanov, Modelling ligand selectivity: an integrated approach Drugs of The Future. ,vol. 32, pp. 17- 17 ,(2007)
Mark Gilbert, Shaymaa Mousa, Shaker A Mousa, None, Current status of anti-vascular endothelial growth factor (VEGF) strategies and future directions Drugs of The Future. ,vol. 33, pp. 515- 525 ,(2008) , 10.1358/DOF.2008.033.06.1221918
Louis J. Lombardo, Francis Y. Lee, Ping Chen, Derek Norris, Joel C. Barrish, Kamelia Behnia, Stephen Castaneda, Lyndon A. M. Cornelius, Jagabandhu Das, Arthur M. Doweyko, Craig Fairchild, John T. Hunt, Ivan Inigo, Kathy Johnston, Amrita Kamath, David Kan, Herbert Klei, Punit Marathe, Suhong Pang, Russell Peterson, Sidney Pitt, Gary L. Schieven, Robert J. Schmidt, John Tokarski, Mei-Li Wen, John Wityak, Robert M. Borzilleri, Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. Journal of Medicinal Chemistry. ,vol. 47, pp. 6658- 6661 ,(2004) , 10.1021/JM049486A
Lee M. Ellis, Daniel J. Hicklin, VEGF-targeted therapy: mechanisms of anti-tumour activity Nature Reviews Cancer. ,vol. 8, pp. 579- 591 ,(2008) , 10.1038/NRC2403
John R. Pollard, Michael Mortimore, Discovery and development of aurora kinase inhibitors as anticancer agents. Journal of Medicinal Chemistry. ,vol. 52, pp. 2629- 2651 ,(2009) , 10.1021/JM8012129
Elias Jabbour, Samih El Ahdab, Jorge Cortes, Hagop Kantarjian, Nilotinib: a novel Bcr-Abl tyrosine kinase inhibitor for the treatment of leukemias Expert Opinion on Investigational Drugs. ,vol. 17, pp. 1127- 1136 ,(2008) , 10.1517/13543784.17.7.1127
Philip A. Harris, Amogh Boloor, Mui Cheung, Rakesh Kumar, Renae M. Crosby, Ronda G. Davis-Ward, Andrea H. Epperly, Kevin W. Hinkle, Robert N. Hunter, Jennifer H. Johnson, Victoria B. Knick, Christopher P. Laudeman, Deirdre K. Luttrell, Robert A. Mook, Robert T. Nolte, Sharon K. Rudolph, Jerzy R. Szewczyk, Anne T. Truesdale, James M. Veal, Liping Wang, Jeffrey A. Stafford, Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor† Journal of Medicinal Chemistry. ,vol. 51, pp. 4632- 4640 ,(2008) , 10.1021/JM800566M
S. Sahtornsumetee, J.N. Rich, Vandetanib, a novel multitargeted kinase inhibitor, in cancer therapy. Drugs of Today. ,vol. 42, pp. 657- 670 ,(2006) , 10.1358/DOT.2006.42.10.1025318
Irene Y. Cheung, Yi Feng, Karen Danis, Neerav Shukla, Paul Meyers, Marc Ladanyi, Nai-Kong V. Cheung, Novel Markers of Subclinical Disease for Ewing Family Tumors from Gene Expression Profiling Clinical Cancer Research. ,vol. 13, pp. 6978- 6983 ,(2007) , 10.1158/1078-0432.CCR-07-1417
Rongshi Li, Alan Pourpak, Stephan W. Morris, Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. Journal of Medicinal Chemistry. ,vol. 52, pp. 4981- 5004 ,(2009) , 10.1021/JM9002395