Parimal Chowdhury's work on smoking related pancreatic disorders.

摘要: Cigarette smoking is a known risk factor for the development of numerous diseases. The role nicotine in induction pancreatic inflammation and cancer as result cigarette has been recognized reported literature. mechanism by which induces such pathologies yet unknown. An understanding proliferative potential primary tumor cells pancreas will allow us to develop measures that ultimately lead intervention, prevention treatment these Studies show can increase cell numbers cer-tain lines, suggesting exposure disruption dynamic balance between death proliferation, required normal functioning cells. We hypothesize oxidative stress acinar thus contributes this disruption. have used AR42J line our study because its stability an immortal physiological similarity Our studies mitogen activated protein kinase signaling induced cells, causing lipid peroxidation subsequent decrease function. data suggest stress, leading injury compromised function, implicating plausible mechanism.