Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus

摘要: Long noncoding RNAs (lncRNAs) have important roles in diverse biological processes. Our previous study has revealed that lncRNA-MALAT1 deregulation is implicated the pathogenesis of diabetes-related microvascular disease, diabetic retinopathy (DR). However, role MALAT1 retinal vasculature remodeling still remains elusive. Here we show expression significantly upregulated retinas STZ-induced rats and db/db mice. knockdown could obviously ameliorate DR vivo, as shown by pericyte loss, capillary degeneration, leakage, inflammation. Moreover, regulate endothelial cell proliferation, migration, tube formation vitro. The crosstalk between p38 MAPK signaling pathway involved regulation function. upregulation represents a critical pathogenic mechanism for diabetes-induced dysfunction. Inhibition may serve potential target anti-angiogenic therapy complications.