Effect of prolonged starvation on glycogen synthase and glycogen synthase phosphatase activity in rat heart.
作者： Mary C. Gannon , Frank Q. Nuttall
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摘要: Rats were fasted 24, 48 or 72 hours to determine the effect of several days without food on glycogen synthase and phosphatase activity in heart. The basal percentage I decreased gradually from approximately 20% fed animals 6% rats starved for hours. Glycogen increased progressively 4.6 mg/g wet weight 7.6 72-hour rats. Thus, there was an inverse relationship between concentration I. total measured at a standardized 50% by 24 starvation then unchanged up decrease correlated directly with insulin 24-72 rapid stimulatory observed delayed This slower response insulin. lost completely proposed mechanism lack is resistance. remains be elucidated.
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D.H. Williamson, J.T. Brosnan, Concentrations of Metabolites in Animal Tissues Methods of Enzymatic Analysis (Second English Edition)#R##N#Volume 4. pp. 2266- 2302 ,(1974) , 10.1016/B978-0-12-091304-6.50093-8
F Q Nuttali, M C Gannon, V A Corbett, M P Wheeler, Insulin stimulation of heart glycogen synthase D phosphatase (protein phosphatase). Journal of Biological Chemistry. ,vol. 251, pp. 6724- 6729 ,(1976) , 10.1016/S0021-9258(17)33005-3
William H. Danforth, GLYCOGEN SYNTHETASE ACTIVITY IN SKELETAL MUSCLE. INTERCONVERSION OF TWO FORMS AND CONTROL OF GLYCOGEN SYNTHESIS. Journal of Biological Chemistry. ,vol. 240, pp. 588- 593 ,(1965) , 10.1016/S0021-9258(17)45214-8
Z Ahmad, A A DePaoli-Roach, P J Roach, Purification and characterization of a rabbit liver calmodulin-dependent protein kinase able to phosphorylate glycogen synthase. Journal of Biological Chemistry. ,vol. 257, pp. 8348- 8355 ,(1982) , 10.1016/S0021-9258(18)34337-0
Chiharu Nakai, James A. Thomas, Control of glycogen synthase phosphatase from rat heart. The role of substrate. Journal of Biological Chemistry. ,vol. 248, pp. 2208- 2213 ,(1973) , 10.1016/S0021-9258(19)44206-3
Chiharu Nakai, James A. Thomas, Properties of a Phosphoprotein Phosphatase from Bovine Heart with Activity on Glycogen Synthase, Phosphorylase, and Histone Journal of Biological Chemistry. ,vol. 249, pp. 6459- 6467 ,(1974) , 10.1016/S0021-9258(19)42179-0
M.E. Payne, T.R. Soderling, Calmodulin-dependent glycogen synthase kinase. Journal of Biological Chemistry. ,vol. 255, pp. 8054- 8056 ,(1980) , 10.1016/S0021-9258(19)70605-X
C Ip, H M Tepperman, P Holohan, J Tepperman, Insulin binding and insulin response of adipocytes from rats adapted to fat feeding. Journal of Lipid Research. ,vol. 17, pp. 588- 599 ,(1976) , 10.1016/S0022-2275(20)41730-4
Michel. DuBois, K. A. Gilles, J. K. Hamilton, P. A. Rebers, Fred. Smith, Colorimetric Method for Determination of Sugars and Related Substances Analytical Chemistry. ,vol. 28, pp. 350- 356 ,(1956) , 10.1021/AC60111A017
James A. Thomas, Keith K. Schlender, Joseph Larner, A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose Analytical Biochemistry. ,vol. 25, pp. 486- 499 ,(1968) , 10.1016/0003-2697(68)90127-9