Nedocromil sodium for chronic asthma in children

摘要: BACKGROUND Currently inhaled corticosteroids are the main stay in maintenance treatment of chronic asthma children. Although play a crucial role management childhood asthma, long-term side effects used children not clearly known. OBJECTIVES The objective this review is to compare safety and efficacy nedocromil sodium with placebo SEARCH STRATEGY We searched Cochrane airway group trials register, controlled Current contents, articles, reference lists articles. also contacted drug manufacturer primary authors for additional citations. abstracts major respiratory society meetings. last search was carried out October 2004 SELECTION CRITERIA Randomised comparing (0 18 years). DATA COLLECTION AND ANALYSIS Both independently assessed trial quality extracted data. Study were information. MAIN RESULTS Fifteen (twelve parallel studies; three crossover recruiting 1422 (837 males 585 females)) included. studies generally good methodological quality. Two large long term six months four years showed conflicting results symptom free days. Short (duration between 4 weeks 12 weeks) that produced some improvement number measures compared including FEV(1), FVC, FEV(1) % predicted, PC20 evening PEF scores. parent's assessment favour (odds ratio (OR) 0.5 (95% CI 0.3 0.8). Nedocromil has profile. only significant effect observed unpleasant taste. There little evidence clinically dose response few recruited participants severe asthma. AUTHORS' CONCLUSIONS A limited small have shown benefit improving lung function symptoms, but regard outcome conflicting. did show consistent on outcomes, whereas several short-term these outcomes. Differing severities at baseline may explain difference milder experiencing less benefit, although discrepancy study findings reflect publication bias. associated very profile no short or long- adverse effects. advantages over terms effects, there need head establish whether control similar, especially mild It yet clear where should sit relation other therapies