Genetic Structure and Its Implications for Genetic Epidemiology: Aleutian Island Populations

摘要: Genome-wide association studies (GWAS) have become a popular approach for identifying genetic variants that influence variation in susceptibility to common, complex diseases. However, findings from such may be biased due population stratification, and several techniques been used adjust its influences on studies. Therefore, given attention diversity across human populations, combination of SNPs or STRs autosomal chromosomes, mitochondrial DNA, NRY chromosome markers should utilized determine whether structure exists the interest. In large cosmopolitan populations reside urban centers, it can difficult assess potential discontinuity possible sources social stratification. contrast, island are geographically isolated as well culturally defined with boundaries more easily circumscribed. This chapter examines indigenous Aleutian Archipelago distribution mtDNA their resulting history geography. Despite forced relocation transplantation some Aleuts commercial purposes by Russians nineteenth century World War II invasion Japanese, disease epidemics, disruption, has maintained DNA sequences. preservation ancient is revealed high correlation between intermatch distances based sequences geographical distances. Yet, there no statistically significant geography distances, NRY, nor The gene reflects one-way flow Russian western European males Aleut females. There considerable asymmetry substructure Islands depending which molecular variability.