Low dose methylphenidate improves freezing in advanced Parkinson’s disease during off-state
作者： L. Pollak , Y. Dobronevsky , T. Prohorov , S. Bahunker , J. M. Rabey
DOI: 10.1007/978-3-211-73574-9_17
关键词:
摘要: Five men with advanced idiopathic Parkinson’s disease (PD) were examined to assess the effect of low dose methylphenidate (MPD) on gait. The patients tested during “off” state before and two hours after intake 10mg MPD while walking an “8 trajectory”. total time, freezing number episodes nonfreezing time assessed. obtained data compared by Wilcoxon Signed Rank test a type I error rate 0.05. results showed statistically significant improvement in all gait parameters intake. Moreover, good correlation grade for each individual characteristic was found. study demonstrates that may improve gait, especially freezing, severe PD, without need exogenous L-dopa. mechanism action PD is further discussed.
springer.com
springerlink.com参考文章(23)
S Fahn, The freezing phenomenon in parkinsonism. Advances in Neurology. ,vol. 67, pp. 53- 63 ,(1995)
K. T. Finnegan, Neurotoxins and monoamine oxidase inhibition: New aspects Movement Disorders. ,vol. 8, ,(1993) , 10.1002/MDS.870080505
J. H. Meador-Woodruff, S. P. Damask, S. J. Watson, Differential expression of autoreceptors in the ascending dopamine systems of the human brain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 8297- 8301 ,(1994) , 10.1073/PNAS.91.17.8297
Hani T. S. Benamer, Jim Patterson, David J. Wyper, Donald M. Hadley, G. J. A. Macphee, Donald G. Grosset, Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Movement Disorders. ,vol. 15, pp. 692- 698 ,(2000) , 10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V
Y. Balash, C. Peretz, G. Leibovich, T. Herman, J. M. Hausdorff, N. Giladi, Falls in outpatients with Parkinson's disease: frequency, impact and identifying factors. Journal of Neurology. ,vol. 252, pp. 1310- 1315 ,(2005) , 10.1007/S00415-005-0855-3
P Seeman, B K Madras, Anti-hyperactivity medication: methylphenidate and amphetamine Molecular Psychiatry. ,vol. 3, pp. 386- 396 ,(1998) , 10.1038/SJ.MP.4000421
John G. Nutt, Julie H. Carter, Gary J. Sexton, The dopamine transporter: Importance in Parkinson's disease Annals of Neurology. ,vol. 55, pp. 766- 773 ,(2004) , 10.1002/ANA.20089
J. P. Seibyl, K. L. Marchek, D. Quinlan, K. Sheff, S. Zoghbi, Y. Zea-Ponce, R. M. Baldwin, B. Fussell, E. O. Smith, D. S. Charney, P. B. Hoffer, R. B. Innis, Decreased single‐photon emission computed tomographic {123I}β‐CIT striatal uptake correlates with symptom severity in parkinson's disease Annals of Neurology. ,vol. 38, pp. 589- 598 ,(1995) , 10.1002/ANA.410380407
H. Tohgi, T. Abe, S. Takahashi, The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients Journal of Neural Transmission - Parkinson's Disease and Dementia Section. ,vol. 5, pp. 27- 34 ,(1993) , 10.1007/BF02260912
Hideo Tohgi, Takashi Abe, Satoshi Takahashi, Junko Takahashi, Humitoshi Hamato, Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms Neuroscience Letters. ,vol. 150, pp. 71- 74 ,(1993) , 10.1016/0304-3940(93)90111-W