Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion

摘要: Abstract It is generally accepted that the intestinal phase of pancreatic secretion initiated by stimulation chemoreceptors sensitive to fat and protein degradation products hydrogen ions. The effect volume osmolality food emptied stomach into duodenum has received less attention. We investigated effects these factors on studying 8 healthy male volunteers (ages 23–69 yr), in random order 3 separate days. On day 1, an amino acid mixture (l-phenylalanine, l-tryptophan) was infused intraduodenally at increasing rates, 0.2, 0.8, 3.2 ml · min −1 . 2, normal saline intestine same rates. 3, mannitol solutions 370, 520, 700 mosmol kg were 0.2 Duodenal contents continuously aspirated via a double-lumen tube PEG 4000 used as recovery marker. All studies repeated 90 later during i.v. infusion atropine (20 μg h ). Increasing volumes acids significantly increase amylase bicarbonate output (p no seen thereafter. responses with ~40% obtained acids. reduced