Current Research into Chemical Synthesis of Phaseolotoxin

摘要: Phaseolotoxin is a chlorosis-inducing Phytotoxin produced by the bacterium Pseudomonas syringae pv. phaseolicola. The structure of phaseolotoxin (Mitchell, 1976), revised in 1984 (Moore et al., 1984), depicted 1 and described chemical name Nδ-(N’-sulpho-diaminophosphinyl)-L-ornithyl-alanylhomoarginine. primary toxic product organism, reversible inhibitor ornithine transcarbamoyl ase (OTC-ase) (Tempi eton 1984; Turner Mitchell, 1985). However, it apparent that different compound operative planta, particularly plants infected P. phaseolicola (Mitchell Bieleski, 1977; Moore 1984). This compound, 2, has Open image new window Chemical Nδ-(N’-sulpho-d1aminophosphinyl)-L-ornithine (Templeton 1985), I refer to this as PSorn. PSorn not bacterial but readily formed from action peptidases leaves 1977), vitro 1976). In contrast phaseolotoxin, potent inactivator OTC-ase