Postnatal development of the T calcium current in cat thalamocortical cells

摘要: Abstract The burst firing of thalamic cells in the adult cat is mainly controlled by a voltage-dependent membrane current that has recently been characterized as being similar to low voltage-activated (i.e. threshold), T-type, Ca 2+ originally described sensory neurons. In those neurons so far studied, well skeletal muscle, threshold shown decrease amplitude or even disappear during embryogenesis first few weeks postnatal life. We have now investigated vivo development present thalamocortical dorsal lateral geniculate nucleus cats aged four 100 days. results show triples from 0.5 nA days after birth over 1.5 adult. However, this increase not accompanied any change its inactivation and activation properties, latency peak time dependence removal. Because these similarities adulthood it likely major role neuronal generation oscillatory activities observed cells.