摘要: Extracellular matrix (ECM) in the heart and vascular wall includes fibrous proteins proteoglycans. Fibrous are classified within two categories: structural (collagen elastin) adhesive molecules (laminin fibronectin). These ECM components important maintenance of both structure function tissues. Myocardial infarction, hypertrophy, hypertension failure well known to be associated with progressive cardiac fibrosis. Vascular hypertrophy thickening has been pathological series events that attends restenosis. The accumulation cardiovascular system plays an role development after myocardial infarction hypertension, as Angiotensin II (angiotensin) transforming growth factor beta 1 play a signalling abnormal these diseases. Administration angiotensin-converting enzyme inhibitor or angiotensin receptor type antagonist is regression fibrosis hypertrophy.
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