Simultaneous determination of nicotinic acid and its metabolites in rat urine by micellar electrokinetic chromatography with photodiode array detection
作者： Masahiro Iwaki , Etsuko Murakami , Masako Kikuchi , Akinori Wada , Taro Ogiso
DOI: 10.1016/S0378-4347(98)00327-2
关键词:
摘要: Nicotinic acid, nicotinamide and their possible metabolites were successfully separated within 17 min by micellar electrokinetic chromatography using 50 mM borate buffer (pH 9.0) containing 150 sodium dodecyl sulfate as the running buffer. Calibration curves for all compounds showed good linearity in a range of 5 microg/ml 250 with correlation. The present method did not require any clean-up procedures made it to determine without interference on photodiode array detector. Urine samples collected from Wistar male rats analyzed after high-dose oral or intravenous administration nicotinic acid nicotinamide. Metabolic pathways are also discussed.
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