Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 25 tumors.

摘要: Lipoblastoma/lipoblastomatosis is an uncommon benign adipose tissue tumor of children. Since 1958, 25 these tumors from 24 patients have been reviewed in the Department Pathology at The Children's Hospital Philadelphia. Tumors were resected 19 boys (79%) and five girls, 20 (84%) < or =5 years age diagnosis. Twenty-three presented as painless superficial soft-tissue masses; one was retroperitoneal discovered because vomiting; hand present birth. occurred extremity (n = 11 patients), head neck 5), groin 2), axilla back 1), chest flank labia retroperitoneum 1). Thirteen on left side, right. Lesions measured 1.0-21.0 cm greatest dimension; 15 (60%) =5.0 cm. largest (retroperitoneal) weighed 450 g. Eleven discrete lipoblastoma, 14 had irregular margins (lipoblastomatosis). Microscopically, displayed adipocytes different stages maturation; lobules bordered by septae that cellular cases; prominent blood vessels myxoid foci 13 cases. Chart review 22 showed recurred 4 after resection; 7 fibrolipoma; incompletely enlarged second resection lipoma. There no metastases. Three also hemangioma. Juvenile aponeurotic fibroma patient near site a lipoblastoma earlier. We conclude lipoblastoma/lipoblastomatosis behaves benignly, occurs both deep sites, occasionally attains large size, may mature, can recur, be associated with other lesions. Complete surgical excision treatment choice.