Fibrinolysis and aspiration of experimental intracerebral hematoma reduces the volume of ischemic brain in rats.

摘要: The hypothesis was tested in rats that brain ischemia by an intracerebral hematoma can be ameliorated fibrinolysis and aspiration of the hematoma. Intraparenchymal blood clots were generated injection 50 microliters autologous into right caudate nucleus two portions seven minutes apart. Thirty or 120 min later 12 recombinant tissue plasminogen activator (rtPA) 0.9% NaCl injected after 30 resolved aspirated. Six hours cerebral flow (CBF) determined 14C-iodoantipyrine autoradiography. Tissue volumes CBF < 10 ml 100 g-1 min-1 determined. Clot lesion volume quantified histologically from serial sections stained for succinate-dehydrogenase (SDH) activity. In rtPA-treated major part could evacuated as well production clot. ischemic (CBF 10) significantly reduced (p 0.05) rtPA group compared to saline-treated control groups irrespective time treatment. contrast, no difference found between experimental when surrounding which had values min-1. a rat model hemorrhage, treatment local followed is effective reducing remaining clot volume.