A high-speed real-time nanopore signal detector

摘要: An improved-accuracy algorithm for real-time nanopore-based signal detection (e.g. base calling) is introduced. The approach based on the cumulative sum technique but employs a decision-directed policy coupled with post-decision correction mechanism. These additions allow improved detector to achieve at least 10× accuracy improvement over previously reported method while tolerating much greater decision threshold variation. As result new can better accommodate high-speed embedded nanopore measurement applications such as DNA sequencing where high-frequency noise and coarse data conversion otherwise profoundly degrade accuracy.