Regulation of complement protein biosynthesis in mononuclear phagocytes.

摘要: Proteins of the complement system (with exception terminal components C6-9) are synthesized in mononuclear phagocytes. The extrahepatic macrophage is therefore an important local source proteins which may serve as a first-line host defence mechanism. Net synthesis and secretion by these cells function maturation phagocytic series, tissue from isolated, state activation. To define some mechanisms for regulation gene expression phagocytes, major histocompatibility complex class III genes C3 have been investigated. These expressed constitutively hepatocytes monocytes/macrophages. In phagocyte, interferon-gamma, at physiological concentrations, effects dose- time-dependent increase factor B C2 mRNA corresponding biosynthesis. This effect specific inasmuch other (e.g. C3) decreased interferon-alpha beta concentrations one to two logs greater only minimal on expression. Endotoxin acting directly monocytes has qualitatively different genes. regulatory being investigated with use murine fibroblasts transfected human DNA bearing relevent