Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study

摘要: BACKGROUND The higher risk of type 2 diabetes in persons with a high waist-to-hip ratio (WHR) or waist-to-thigh (WTR) has mostly been attributed to increased visceral fat accumulation. However, smaller hip thigh circumference may also explain the predictive value WHR WTR for diabetes. OBJECTIVE This study considered prospectively association and circumferences, independent waist circumference, incidence DESIGN Hoorn Study is population-based cohort A total 1357 men women aged 50-75 y nondiabetic at baseline participated 6-y follow-up examination. Glucose tolerance was assessed by use 75-g oral-glucose-tolerance test. Baseline anthropometric measurements included body mass index (BMI) waist, hip, circumferences. RESULTS Logistic regression analyses showed that 1-SD larger gave an odds (OR) developing 0.55 (95% CI: 0.36, 0.85) 0.63 (0.42, 0.94) women, after adjustment age, BMI, circumference. adjusted ORs were 0.79 (0.53, 1.19) 0.64 (0.46, 0.93) women. In contrast positively associated these models (ORs ranging from 1.60 2.66). CONCLUSION Large circumferences are lower diabetes, independently whereas risk.