摘要: Intervertebral disc degeneration (IDD) is an important cause of low back pain. Recent evidence suggests that in addition to abnormal and excessive mechanical loading, inflammation may be a key driver for both IDD Obesity, known risk factor IDD, now increasingly being recognized as systemic inflammatory state with adipokines postulated likely mediators. The aim this review was summarize the current literature regarding role pathophysiology IDD. A systematic search performed using OVID Medline, EMBASE PubMed databases identify all studies assessing adipokines. Fifteen were included present review. Leptin most commonly assessed adipokine. Ten 15 conducted humans; three rats two humans rats. Studies focused on variety topics ranging from receptor identification, pathway analysis, genetic associations, proteonomics. Currently, data human animal experiments demonstrate significant effects leptin adiponectin internal milieu intervertebral discs. However, future are needed determine molecular relationships between avenues therapeutic targets.
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Bin Yuan, Liangliang Huang, Ming Yan, Shilei Zhang, Yongfeng Zhang, Boquan Jin, Ying Ma, Zhuojing Luo, Adiponectin Downregulates TNF-α Expression in Degenerated Intervertebral Discs. Spine. ,vol. 43, pp. 1- ,(2018) , 10.1097/BRS.0000000000002364
Zengjie Zhang, Tianzhen Xu, Jiaoxiang Chen, Zhenxuan Shao, Ke Wang, Yingchao Yan, Congcong Wu, Jialiang Lin, Haoli Wang, Weiyang Gao, Xiaolei Zhang, Xiangyang Wang, Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration. Cell Death and Disease. ,vol. 9, pp. 980- ,(2018) , 10.1038/S41419-018-1024-9
Anand H Segar, Jeremy C T Fairbank, Jill Urban, Leptin and the intervertebral disc: a biochemical link exists between obesity, intervertebral disc degeneration and low back pain-an in vitro study in a bovine model. European Spine Journal. ,vol. 28, pp. 214- 223 ,(2019) , 10.1007/S00586-018-5778-7
Clara Ruiz-Fernández, Vera Francisco, Jesus Pino, Antonio Mera, Miguel Angel González-Gay, Rodolfo Gómez, Francisca Lago, Oreste Gualillo, Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link? International Journal of Molecular Sciences. ,vol. 20, pp. 2030- ,(2019) , 10.3390/IJMS20082030
Scotece M, Gualillo O, Gómez R, Conde J, Pino J, López, Gómez-Reino Jj, Lago F, Adipokines: novel players in rheumatic diseases. Discovery Medicine. ,vol. 15, pp. 73- 83 ,(2013)
Vinod K Podichetty, The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. Cellular and Molecular Biology. ,vol. 53, pp. 4- 18 ,(2007)
Mathias Fasshauer, Matthias Blüher, Adipokines in health and disease Trends in Pharmacological Sciences. ,vol. 36, pp. 461- 470 ,(2015) , 10.1016/J.TIPS.2015.04.014
Wei Ding, Changqing Zhao, Lei Cao, Kai Zhang, Wei Sun, Youzhuanu Xie, Hua Li, Jie Zhao, Leptin induces terminal differentiation of rat annulus fibrosus cells via activation of MAPK signaling. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 296, pp. 1806- 1812 ,(2013) , 10.1002/AR.22806
Evelien I. T. de Schepper, Jurgen Damen, Joyce B. J. van Meurs, Abida Z. Ginai, Maria Popham, Albert Hofman, Bart W. Koes, Sita M. Bierma-Zeinstra, The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features. Spine. ,vol. 35, pp. 531- 536 ,(2010) , 10.1097/BRS.0B013E3181AA5B33
OMAR F. KHABOUR, LAMA ABU-RUMEH, MUHAMMED AL-JARRAH, MOHAMMED JAMOUS, FARAH ALHASHIMI, Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration Experimental and Therapeutic Medicine. ,vol. 8, pp. 1340- 1344 ,(2014) , 10.3892/ETM.2014.1909