Functional dyspepsia susceptibility is associated with TGFB1 gene polymorphisms (RS4803455, RS1800469) in H pylori‐negative Chinese population

摘要: BACKGROUND We previously published that altered expression of gastric TRPV1, BDNF, and peripheral cytokines was present in patients with functional dyspepsia. herein examine whether genetic predisposition biomarkers influences dyspeptic, sleep, mood symptoms FD without previous infection. METHODS Consecutive adult (Rome III) no recent history gastroenteritis asymptomatic age- sex-matched healthy controls were recruited for upper endoscopy. Subjects GERD IBS as predominant symptoms, diabetes mellitus, current or H pylori infection, psychiatric illness, use NSAID PPI excluded. The associations dyspeptic sleep quality, evaluated. Genetic polymorphisms TGFB1, TNF, COMT, IL6, IL8, IL10, IL12 analyzed. KEY RESULTS Twenty-nine male 104 female age matched (±3 years) 81 subjects. All had postprandial distress syndrome (PDS) subtype (PDS: 130, EPS: 3). SNPs TGFB1 showed significant after sex adjustment [for RS4803455: the codominant model (C/A, OR = 0.34 (0.18-0.65), P = .004); dominant (genotype C/C vs C/A-A/A, OR = 0.42 (0.23-0.77), overdominant C/C-A/A C/A, OR = 0.38 (0.21-0.70), P < .001)] RS1800469: A/A A/G-G/G, OR = 0.52 (0.27-0.99), P = .043)]. A allele RS4803455 associated higher HADS depression score (P = .05) epigastric burning sensation(P = .01). CONCLUSIONS AND INFERENCES Our data predispose difference which may influence severity